Karim Nader, PhD, Professor, Department of Psychology, McGill University
Talk Title: We Forgot Forgetting: Evidence for Forgetting Being an Active Neurobiological Process
Brain & Behaviour Seminar Series 2013-2014 SPECIAL LECTURE
Abstract: Forgetting is among the least well understood basic memory phenomena. Recent research into long-term memory maintenance may shed light on molecular processes underlying forgetting. Long-term memory persistence is linked to regulation of GluA2-AMPA receptor trafficking, and memory strength to their levels of post-synaptic expression. Therefore, we blocked internalization of these receptors in the hippocampus after learning. This prevented normal forgetting of object location memory in rats. The same treatment potentiated new learning, rather than impairing it as interference theory would suggest. Blocking GluN2b-containing NMDA receptors also attenuated forgetting, implicating them in GluA2-AMPA receptor internalization. Linking the decay concept of forgetting to a neurobiological substrate, we here identify a molecular pathway in the hippocampus involved in the active removal of memories over time.
Reception to follow in the Psychology Lounge, room 4043 Sidney Smith Hall
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