Robin Green, PhD, CPsych, Canada Research Chair & Senior Scientist, Toronto Rehabilitation Institute
Title: Characterization and Mechanisms of Neurodegeneration in ChronicModerate-Severe Traumatic Brain Injury
Ebbinghaus Empire Series 2014-2015
VIDEO RECORDING OF TALK
Abstract: We have traditionally assumed that when the brain sustains neurological trauma, it remains stable after acute injuries have resolved. This program of research focuses on the progressive, deteriorative course of moderate-severe traumatic brain injury (TBI), and on the mechanisms that underlie this deterioration. Our lab has shown that at multiple levels of function (brain, cognition, emotion, psychosocial function), the course of TBI often worsens with time. Focusing on the hippocampi and its substructures, we examine a number of potentially moderating influences on atrophy from 5 to 12 to 24 months post-TBI, including demographic and injury factors, patterns of deterioration across brain structures, environmental engagement/enrichment, and anxiety. Anxiety has recently been identified as playing a causal role in Alzheimer's Disease; our research suggests a similar causal relationship between anxiety and neurodegeneration in the chronic stages of moderate-severe TBI. Understanding mechanisms of neurodegeneration in TBI offers implications for the development of treatments to offset deterioration, and may have implications for broader, cross-cutting principles of neurodegeneration (and treatment) across disorders.
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