Dr. John Yeomans, Professor, Psychology Department, University of Toronto, St. George Campus
Talk Title: Mouse Pup Songs and Schizophrenia: From Hormones to Hippocampus
Brain & Behaviour Seminar Series 2014-2015
Reception to follow in the Psychology Lounge, room 4043, Sidney Smith Hall
Abstract: Isolated mouse pups communicate by ultrasonic vocalizations to obtain maternal care. Fewer vocalizations occur in D2, M5 and GTF2i deficient mice, due to maternal genotype, as well as pup genotype. The roles of prolactin, oxytocin and endogenous opiates are studied. Positive symptoms of schizophrenia are associated with loss of GABA
neurons, and increased functional activity, in the ventral hippocampus. We studied the ventral hippocampus in adult mice by chemical stimulation, and by inhibition of GABA neurons using AAV-M4D. Inhibition of parvalbumin neurons in PV-Cre mice reduced prepulse inhibition of startle and spontaneous alternation, but not locomotion. Inhibition of GABA neurons more generally in GAD65-Cre mice increased spontaneous and amphetamine-induced locomotion, but did not alter prepulse inhibition. The roles GABA neuron development, and GABA-A receptor inhibition, in mental health and excitation-inhibition balance, are discussed.
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